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Same Time Next Tuesday follows Joe, a sleazy mechanic in the process of working out his issues and becoming a better man, recounting an incident that shakes up his life to his therapist, Horacio.
The story jumps back and forth between discussions in Horacio's office, which examine and develop Joe and his hangups, and flashbacks that showcase Joe's recounting of events, occasionally interrupted by the pair to give commentary as literal talking heads.
The office scenes use a blend of 2D character sprites and a 3D-rendered background, with camera movement and sprite animations adding visual interest, while the flashback scenes are seen in first person from Joe's point of view, with plenty of stylistic flair to sell the motion comic look.
Same Time Next Tuesday is split in three therapy sessions, with Joe updating Horacio on the events as they play out, plus a 10-15 minute long excerpt from one of Joe's sessions before the start of the story (dubbed session 0), which establishes Joe's goals in therapy and recaps events of the previous comics to put newcomers up to speed.